HD Proteome Base
The novel data repository termed HD Proteome Base stores and displays
quantitative proteome profiles related to Huntington's disease (HD).
The first large-scale study containstime- and tissue-resolved
proteome profiles of Huntington’s Disease (HD) Mouse Knock-In Allelic Series.
The user-friendly web portal allows the researcher to query for
proteins and to visualize their expression across the CAG repeat
length series and across different brain tissues (striatum, cortex,
cerebellum, and hippocampus), as well as peripheral tissues (liver,
muscle, and heart). With this effort, we hope to help multiple
research teams across the globe to gain a better understanding of the
huntingtin biology and potentially contribute to the development of
new therapies for HD.
This repository supplements the data repositories available in
HDinHD.
New Data Sets
Time- and Tissue-Resolved Proteome Analysis of Huntington’s Disease
Mouse Knock-In Allelic Series (04/2017):
In order to gain a deeper understanding of the
pathophysiological mechanisms in Huntington’s disease (HD), we
compared the proteomes between wild-type and heterozygous Huntingtin
knock-in mice with increasing CAG repeat lengths in a number of
different brain regions and peripheral tissues at three different
ages (2, 6, and 10 months).
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R6/2 Baseline Phosphoproteome (05/2019):
Animal models play
a critical role in the study of Huntington’s disease, for
example to elucidate underlying molecular mechanisms or to develop
novel therapeutic venues. One of the first transgenic mouse models
of HD, the R6/2 line, has been described in 1996 and has since
become one of the most studied models of the disease. Here we performed
comprehensive quantitative phosphoproteome and proteome analyses of
striatum of one, two, and three months old mice of R6/2 and wild-type
genotypes.
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|
Protein Query
Statistics
| Species |
Experiments |
Proteins |
Peptides |
Evidences |
| Mouse |
664 |
21,226 |
520,258 |
1,828,514 |
|
