HD Proteome Base

The novel data repository termed HD Proteome Base stores and displays quantitative proteome profiles related to Huntington's disease (HD). The first large-scale study containstime- and tissue-resolved proteome profiles of Huntington’s Disease (HD) Mouse Knock-In Allelic Series. The user-friendly web portal allows the researcher to query for proteins and to visualize their expression across the CAG repeat length series and across different brain tissues (striatum, cortex, cerebellum, and hippocampus), as well as peripheral tissues (liver, muscle, and heart). With this effort, we hope to help multiple research teams across the globe to gain a better understanding of the huntingtin biology and potentially contribute to the development of new therapies for HD. This repository supplements the data repositories available in HDinHD.

New Data Sets

Time- and Tissue-Resolved Proteome Analysis of Huntington’s Disease Mouse Knock-In Allelic Series (04/2017): In order to gain a deeper understanding of the pathophysiological mechanisms in Huntington’s disease (HD), we compared the proteomes between wild-type and heterozygous Huntingtin knock-in mice with increasing CAG repeat lengths in a number of different brain regions and peripheral tissues at three different ages (2, 6, and 10 months). Go to project

Protein Query

Search protein by gene or protein name:

Statistics

Species Experiments Proteins Peptides Evidences
Mouse 654 20,277 501,669 1,620,037