HD Proteome BaseThe novel data repository termed HD Proteome Base stores and displays quantitative proteome profiles related to Huntington's disease (HD). The first large-scale study containstime- and tissue-resolved proteome profiles of Huntington’s Disease (HD) Mouse Knock-In Allelic Series. The user-friendly web portal allows the researcher to query for proteins and to visualize their expression across the CAG repeat length series and across different brain tissues (striatum, cortex, cerebellum, and hippocampus), as well as peripheral tissues (liver, muscle, and heart). With this effort, we hope to help multiple research teams across the globe to gain a better understanding of the huntingtin biology and potentially contribute to the development of new therapies for HD. This repository supplements the data repositories available in HDinHD.
New Data Sets
Time- and Tissue-Resolved Proteome Analysis of Huntington’s Disease Mouse Knock-In Allelic Series (04/2017): In order to gain a deeper understanding of the pathophysiological mechanisms in Huntington’s disease (HD), we compared the proteomes between wild-type and heterozygous Huntingtin knock-in mice with increasing CAG repeat lengths in a number of different brain regions and peripheral tissues at three different ages (2, 6, and 10 months). Go to project
R6/2 Baseline Phosphoproteome (05/2019): Animal models play a critical role in the study of Huntington’s disease, for example to elucidate underlying molecular mechanisms or to develop novel therapeutic venues. One of the first transgenic mouse models of HD, the R6/2 line, has been described in 1996 and has since become one of the most studied models of the disease. Here we performed comprehensive quantitative phosphoproteome and proteome analyses of striatum of one, two, and three months old mice of R6/2 and wild-type genotypes. Go to project