HD Proteome Base
The novel data repository termed HD Proteome Base stores and displays
quantitative proteome profiles related to Huntington's disease (HD).
The first large-scale study containstime- and tissue-resolved
proteome profiles of Huntington’s Disease (HD) Mouse Knock-In Allelic Series.
The user-friendly web portal allows the researcher to query for
proteins and to visualize their expression across the CAG repeat
length series and across different brain tissues (striatum, cortex,
cerebellum, and hippocampus), as well as peripheral tissues (liver,
muscle, and heart). With this effort, we hope to help multiple
research teams across the globe to gain a better understanding of the
huntingtin biology and potentially contribute to the development of
new therapies for HD.
This repository supplements the data repositories available in
New Data Sets
Time- and Tissue-Resolved Proteome Analysis of Huntington’s Disease
Mouse Knock-In Allelic Series (04/2017):
In order to gain a deeper understanding of the
pathophysiological mechanisms in Huntington’s disease (HD), we
compared the proteomes between wild-type and heterozygous Huntingtin
knock-in mice with increasing CAG repeat lengths in a number of
different brain regions and peripheral tissues at three different
ages (2, 6, and 10 months).
Go to project